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Hypersensitivity reaction. Anaphylactic/anaphylactoid reactions (including shock and fatalities) have been reported with the use of cefixime. Before therapy with SUPRAX is instituted.careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins.penicillins.or other drugs. Discontinue use if a reaction occurs. Clostridium difficile associated diarrhea. Evaluate if diarrhea occurs. Dose Adjustment in Renal Impairment. The dose of SUPRAX should be adjusted in patients with renal impairment and those undergoing continuous cheap suprax antibiotic peritoneal dialysis and hemodialysis. Coagulation Effects. Cephalosporins.including SUPRAX.may be associated with a fall in prothrombin activity. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. Phenylketonurics. SUPRAX Chewable Tablets contain aspartame.a source of phenylalanine.

Lifetime studies in animals to evaluate carcinogenic potential have not been conducted. Cefixime did not cause point mutations in bacteria or mammalian cells.DNA damage.or chromosome damage in vitro and did not exhibit clastogenic potential in vivo in the mouse micronucleus test. In rats.fertility and reproductive performance were not affected by cefixime at doses up to 25 times the adult therapeutic dose.

The dose of Suprax should be adjusted in patients with renal impairment as well as those undergoing continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD). Patients on dialysis should be monitored carefully [see DOSAGE AND ADMINISTRATION ].

The differences in the side effects of and Dosage.drug interactions.and pregnancy and breastfeeding for cefdinir and cefixime vary by drug.

Elevated carbamazepine levels have been reported in postmarketing experience when cefixime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

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