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Coadministration with aluminum hydroxide gel 1200 mg may result in a decrease in innopran concentrations.

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Information about Innopran.

Hypokalemia may be avoided or treated by use of potassium supplements or foods with a high potassium content.

Beta-blockers.like InnoPran XL.may mask tachycardia occurring with hypoglycemia.but other manifestations such as dizziness and sweating may not be significantly affected.

CYP1A2 and CYP2C19 Inducers. CYP1A2 inducers (e.g..phenytoin.montelukast.smoking) and CYP2C19 inducers (e.g. rifampin) decrease the plasma levels of propranolol resulting in a loss of efficacy [see Clinical Pharmacology (12.7)] .

Beta-blockers.like INNOPRAN XL.can cause depression of myocardial contractility and may precipitate heart failure and cardiogenic shock. If signs or symptoms of heart failure develop.treat the patient according to recommended guidelines. It may be necessary to lower the dose of INNOPRAN XL or to discontinue it.

Chronically administered beta-blocking therapy.including InnoPran XL.should not be routinely withdrawn prior to major surgery. however.the impaired buy innopran er of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.

Elevated systolic or diastolic pressure causes increased cardiovascular risk.and the absolute risk increase per mmHg is greater at higher blood pressures.so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk.so the buy innopran er benefit is greater in patients who are at higher risk independent of their hypertension (for example.patients with diabetes or hyperlipidemia).and such patients buy innopran er be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Caution should be exercised when administering InnoPran XL with drugs that slow A-V nodal conduction.e.g..digi-talis.lidocaine and calcium channel blockers.

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