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Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio.which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5).which is responsible for degradation of cGMP in the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum. When sexual stimulation causes local release of NO.inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum.resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
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Though arginine is required to make nitric oxide.and nitric oxide is required to dilate blood vessels and have an erection.”that doesn't mean eating something that is rich in citrulline will make enough arginine that it will lead to better penile erections. Goldstein says.
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