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Bupropion.levodopa.and amantadine have dopamine agonist effects. CNS toxicity has been reported when bupropion was coadministered with levodopa or amantadine. Adverse reactions have included restlessness.agitation.tremor.ataxia.gait disturbance.vertigo.and dizziness. It is presumed that the toxicity results from cumulative dopamine agonist effects. Use caution when administering WELLBUTRIN concomitantly with these drugs.

The risk of seizure appears to be dose-related. Other risk factors are related to patient factors e.g..severe head injury.arteriovenous malformation.CNS tumor or CNS infection.or severe stroke.concomitant medications that lower the seizure threshold (e.g..other bupropion products.antipsychotics.tricyclic antidepressants.theophylline.and purchase bupron side corticosteroids).metabolic disorders.illicit drug use.abuse or misuse purchase bupron side prescription drugs such as CNS stimulants.diabetes mellitus treated with oral hypoglycemics or insulin.treatment with anorectic drugs.and excessive use of alcohol.benzodiazepines.sedative/hypnotics.or opiates.

Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid.linezolid.phenelzine.rasagiline.selegiline.and tranylcypromine.

Use this medication regularly in order to get the most benefit from it. To help you remember.use it at the same times each day.

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