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This Medication Guide has been approved by the U.S. Food and Drug Administration.

Table 13. Effect of Pioglitazone Coadministration on Systemic Exposure of Other Drugs.

In animal models of diabetes.pioglitazone reduces the hyperglycemia.hyperinsulinemia.and hypertriglyceridemia characteristic of insulin-resistant states such as type 2 diabetes. The metabolic changes produced by pioglitazone result in increased responsiveness duetact how much insulin-dependent tissues and are observed in numerous animal models of insulin resistance.

It may be harder to control your blood sugar when your body is stressed (e.g..due to fever.infection.injury.or surgery). In these cases.consult your doctor because you may require a change in your treatment plan.medications.or blood sugar testing.

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Pioglitazone hydrochloride was not mutagenic in a battery of genetic toxicology studies.including the Ames bacterial assay.a mammalian cell forward gene mutation assay (CHO/HPRT and AS52/XPRT).an in vitro cytogenetics assay using CHL cells.an unscheduled DNA synthesis assay.and an in vivo micronucleus assay.

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since the minimum dose of pioglitazone in duetact exceeds 15 mg, patients taking concomitant strong cyp2c8 inhibitors should switch to individual components of duetact, unless the prescribing health care provider determines that the benefit of duetact clearly outweighs the risk of increased pioglitazone exposure see dosage and administration and clinical pharmacology .

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