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The primary nicotinic effects are muscle spasms.fasciculation and muscular weakness.

Atropine may also be used to abolish or obtund gastrointestinal side effects or other muscarinic reactions. but such use.by masking signs of overdosage.can lead to inadvertent induction of cholinergic crisis.

Pyridostigmine bromide is contraindicated in mechanical intestinal or urinary obstruction.and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects.as discussed below.

When relatively large doses of Mestinon are taken by myasthenic patients it may be necessary to give atropine or other anticholinergic drugs to counteract the muscarinic effects. It should be noted that the slower gastro-intestinal motility caused by these drugs may affect the absorption of Mestinon.

Although certain medicines should not be used together at all.in other cases two different medicines may be used mestinon cost even if an interaction might occur. In these cases.your doctor may want to change the dose.or other precautions may be necessary. When you are taking any of these medicines.it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

MESTINON belongs to a group of medicines called cholinergic antimyasthenics. It works by preventing the breakdown of a chemical called acetylcholine. This chemical is needed to stimulate muscle movement.

MATERIALS AND METHODS. A stock solution of Mestinon was prepared by dissolving Mestinon tablet in normal saline. A serial dilution of Mestinon solutions was then prepared from this stock solution. Fresh whole blood from a normal healthy individual was added to this series of diluted Mestinon solutions. These samples were then tested for platelet aggregation using Chrono-log platelet impedance aggregometer with various platelet agonists. Mestinon-free whole blood sample was used for control. The patient's whole blood sample taken at the time of bruises was also tested for platelet aggregation using the same method.

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it is not known whether mestinon passes into breast milk or if it could harm a nursing baby.

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